A Vampyre Story worked nice on Wine on an old computer with Mint Xfce when I played it last year. Only had to set Wine as windowed full screen, since the game got issues when alt-tabbing. Also worth noting it requires DirectX on Windows, so you’ll have to use DXVK.
Haven’t seen any PICO-8 games lag on Linux, and both Celeste Classic games were released on PICO-8.
Dust: An Elysian Tail might be playable, bar maybe two areas (one mandatory) that have a lot going on.
Slay the Spire should run fine, but I had to sideload an older version of OpenJDK to get it working (maybe 8 or 11; don’t remember which exactly).
Songs for A Hero also seems to run fine.
Tanglewood is a Mega Drive homebrew, so should be playable on any emulators your PC can run.
Va-11 Hall-A: Cyberpunk Bartender Action also runs fine.
Böbl and Nix: The Paradox Relic should both run fine on NES emulators.
I’m seldom picky about what I play, so, by extension, expect to see little to no consistency in what I’d recommend:
#hasicontent 8Doors: Arum’s Afterlife Adventure A Vampyre Story ABZÛ Atari Vault Batman: Arkham Asylum Game of the Year Edition Batman: Arkham City - Game of the Year Edition Battle Chef Brigade Deluxe BlazBlue: Continuum Shift Extended Bloodstained: Curse of the Moon Bunny Swordmaster Story Catherine Classic Celeste Celeste Classic Celeste Classic 2 Child of Light Dandara: Trials of Fear Edition Devil May Cry 4 Devil May Cry HD Collection Downwell Dreaming Sarah Dusk Child Dust: An Elysian Tail Etherborn Final Fantasy VI Final Fantasy VII FINAL FANTASY X/X-2 HD Remaster Final Fantasy XII The Zodiac Age Grey-Box Testing GundeadliGne Gundemonium Recollection Hitogata Happa Injustice: Gods Among Us Ultimate Edition Ittle Dew Kimmy Kitsune Zero Knight Club LiEat Mary Skelter 2 & Mary Skelter: Nightmares (revamped & retconed version; included as an unlockable in Mary Skelter 2) Mary Skelter: Nightmares (OG version; still being sold) Metal Slug Metal Slug 3 Micro Mages Minecraft Minoria Mobile Light Force (aka Gunbird) Moero Chronicle Momodora Momodora II Momodora III Momodora: Reverie Under The Moonlight Ni no Kuni: Wrath of the White Witch No More Heroes No More Heroes 2: Desperate Struggle Okami One Strike Phoenotopia (Adobe Flash version; didn’t play the remake yet) Portal Rabi-Ribi Remember Me Riddled Corpses Saints Row: The Third Senran Kagura Bon Appétit Shantae and the Pirate’s Curse Shantae: Half-Genie Hero Slay the Spire Slipways Classic Songs for a Hero: Definitive Edition (“A Lenda do Herói - Edição Definitiva” in its Portuguese name) Starbound Super Dungeon Boy Tanglewood The Corruption Within The Deed Unparallel Va-11 Hall-A: Cyberpunk Bartender Action Wake Up Wishing Sarah Wonder Boy in Monster World | Wonder Boy V: Monster World III World of Final Fantasy コテ・DE・メクール 真・魔王ゴルベリアス 先取り横スクロール面